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ARID4A is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described.
Gene Name: | AT rich interactive domain 4A (RBP1-like) |
Synonyms: | ARID4A, RBBP-1, RBBP1, RBP-1 |
Target Sequences: | NM_002892 NP_002883.3 |
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