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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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ARID1B / BAF250B
AT rich interactive domain 1B (SWI1-like)
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically.
| Gene Name: | AT rich interactive domain 1B (SWI1-like) |
| Synonyms: | ARID1B, 6A3-5, BRG1-associated factor 250b, BRG1-binding protein ELD/OSA1, DAN15, ELD/OSA1, ELD (eyelid)/OSA protein, KIAA1235, MRD12, HOsa2, OSA2, Osa homolog 2, RP11-419L10.1, BAF250B, BRG1-binding protein hELD/OSA1, p250R |
| Target Sequences: | NM_020732 NP_065783.3 Q8NFD5 |
Publications (1)
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