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ARHU / RHOU
ras homolog family member U
Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.
| Gene Name: | ras homolog family member U |
| Family/Subfamily: | Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806 |
| Synonyms: | RHOU, ARHU, CDC42-like GTPase 1, CDC42L1, DJ646B12.2, FJ646B12.2, G28K, GTP-binding protein-like 1, GTP-binding protein SB128, HG28K, GTP-binding protein like 1, Ras homolog family member U, Rho GTPase-like protein ARHU, Ryu GTPase, Ras-like gene family member U, Wnt-1 responsive Cdc42 homolog, WRCH-1, WRCH1 |
| Target Sequences: | NM_021205 NP_067028.1 Q7L0Q8 |
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