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Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation.
Gene Name: | Rac/Cdc42 Guanine Nucleotide Exchange Factor (GEF) 6 |
Synonyms: | ARHGEF6, Alpha-PIX, COOL2, MRX46, PIXA, AlphaPIX, Cool-2, KIAA0006 |
Target Sequences: | NM_004840 BAA04985.1 Q15052 |
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