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Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
Gene Name: | Rho guanine nucleotide exchange factor (GEF) 4 |
Synonyms: | ARHGEF4, ASEF1, ASEF, GEF4, KIAA1112, STM6 |
Target Sequences: | NM_015320 NP_056135.2 Q9NR80 |
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