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Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.
Gene Name: | Rho/Rac guanine nucleotide exchange factor (GEF) 18 |
Synonyms: | ARHGEF18, p114-RhoGEF, KIAA0521, SA-RhoGEF, Septin-associated RhoGEF, p114RhoGEF, p114-RHO-GEF |
Target Sequences: | NM_015318 NP_056133.2 Q6ZSZ5 |
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