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ARHGEF1
Rho guanine nucleotide exchange factor (GEF) 1
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
| Gene Name: | Rho guanine nucleotide exchange factor (GEF) 1 |
| Synonyms: | ARHGEF1, 115-kD protein, Arp2/3 complex 34 kd subunit, GEF1, LBCL2, p115RhoGEF, LSC, Lsc homolog, SUB1.5, p115-RHOGEF |
| Target Sequences: | NM_004706 NP_004697.2 Q92888 |
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