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ARFGAP1

ADP-ribosylation factor GTPase activating protein 1

GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.

Gene Name: ADP-ribosylation factor GTPase activating protein 1
Synonyms: ARFGAP1, ARF GAP 1, ARF1GAP, ARF1 GAP, BA261N11.3, GAP protein, HRIHFB2281
Target Sequences: NM_018209 NP_060679.1 Q8N6T3

Publications (1)

1
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Zhang Q, Major MB, Takanashi S, Camp ND, Nishiya N, Peters EC, Ginsberg MH, Jian X, Randazzo PA, Schultz PG, Moon RT, Ding S. Proceedings of the National Academy of Sciences of the United States of America. 2007 104:7444-8. [PubMed:17460038] [PMC:PMC1863490]

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Proteins (8)
Over-Expression Lysate (4)
Recombinant (4)
ARFGAP1 (8)
No (8)
GST (2)
Myc-DDK (Flag) (6)
Human (6)
293T Cells (2)
HEK 293 Cells (4)
Wheat Germ Extract (2)
Purified (2)
ARFGAP1 Protein - Purified recombinant protein ARFGAP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
45.5 kDa
20 µg/$1,107
ARFGAP1 Protein - 12.5% SDS-PAGE of human ARFGAP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
71.28 kDa
10 µg/$479; 25 µg/$670
ARFGAP1 Protein - 12.5% SDS-PAGE of human ARFGAP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
71.1 kDa
10 µg/$479; 25 µg/$670
ARFGAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
45.5 kDa
20 µg/$150
ARFGAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
44.5 kDa
20 µg/$150
ARFGAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
45.5 kDa
100 µg/$494
ARFGAP1 Protein - Purified recombinant protein ARFGAP1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
44.5 kDa
20 µg/$1,107
ARFGAP1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
44.5 kDa
100 µg/$494
Viewing 1-8 of 8 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).