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ARF1

ADP-ribosylation factor 1

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles. The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasicity of excitatory synapses and spine shrinkage during long-term depression (LTD).

Gene Name: ADP-ribosylation factor 1
Family/Subfamily: Ras GTPase superfamily IPR001806 , not assigned-Ras GTPase superfamily IPR001806
Synonyms: ARF1, ADP-ribosylation factor 1
Target Sequences: NM_001658 NP_001649.1 P84077

Publications (1)

1
p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. Luo W, Wang Y, Reiser G. The Journal of biological chemistry. 2007 282:30246-55. (WB) [PubMed:17693410]

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ARF1 (56)
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ARF1 Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution of 1:100
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
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ARF1 Mouse anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$801
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ARF1 Mouse anti-Human Monoclonal (HRP) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
HRP Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (Biotin) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Biotin Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (FITC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
FITC Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (APC) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
APC Conjugated
100 µl/$1,027
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ARF1 Mouse anti-Human Monoclonal (PE) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
PE Conjugated
100 µl/$1,027
ARF1 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$341
ARF1 Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
ARF1 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using ARF1 Polyclonal Antibody at dilution of 1:25.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
ARF1 Antibody - ARF1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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ARF1 Rabbit anti-Human Polyclonal (aa80-106) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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ARF1 Mouse anti-Human Monoclonal (FITC) (3F1) Antibody
Human
ICC, IF
FITC Conjugated
0.05 mg/$634
ARF1 Antibody
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ARF1 Mouse anti-Human Monoclonal (AT1B3) Antibody
Human
ELISA, WB
Unconjugated
50 µl/$303; 100 µl/$365
ARF1 Antibody - Western blot analysis of ARF1 using HT29 whole lysates.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ARF1 Antibody - Immunofluorescence analysis of HeLa cells using ARF1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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ARF1 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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ARF1 Mouse anti-Human Monoclonal (4G6) Antibody
Human
ELISA
Unconjugated
100 µg/$423
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ARF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Viewing 1-25 of 56 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).