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AREG / Amphiregulin

amphiregulin

AREG / Amphiregulin is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.

Gene Name: amphiregulin
Synonyms: AREG, Amphiregulin, CRDGF, SDGF
Target Sequences: NM_001657 NP_001648.1 P15514

Publications (2)

1
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Maximilian Strunz , Lukas M Simon , Meshal Ansari, Jaymin J Kathiriya, Ilias Angelidis, Christoph H Mayr, George Tsidiridis, Marius Lange, Laura F Mattner, Min Yee, Paulina Ogar, Arunima Sengupta, Igor Kukhtevich, Robert Schneider, Zhongming Zhao, Carola Voss, Tobias Stoeger, Jens H L Neumann, Anne Hilgendorff, Jürgen Behr, Michael O'Reilly, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff, Harold A Chapman, Fabian J Theis, Herbert B Schiller. Nature communications. 2020 July;11:3559. [Full Text Article] [PubMed:32678092] [PMC:PMC7366678] Related Antibodies: LS-B13911.
2
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn. iScience. 2021 Sep;24:103086. [Full Text Article] [PubMed:34568799] [PMC:PMC8449240]

☰ Filters
Products
Proteins (16)
Over-Expression Lysate (2)
Recombinant (14)
AREG / Amphiregulin (16)
No (15)
Yes (1)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
GST, N-terminus + His, C-terminus (1)
His-GST (2)
His-T7 (1)
Myc-DDK (Flag) (2)
Bovine (1)
Human (12)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (11)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (6)
Biologically active (4)
Select
HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15~20 kDa (SDS-PAGE)
50 µg/$296; 10 µg/$253
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
11.3 kDa
10 µg/$268; 50 µg/$349
AREG / Amphiregulin Protein - BALB/3T3 cell proliferation induced by mouse amphiregulin.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 98 amino acid recombinant protein has a predicted molecular mass of approximately 11.3 kD. The DTT-reduced and non-reduced protein migrate at approximately 16 kD and by SDS-PAGE. The N-terminal amino acid is Ser.
10 µg/$268; 25 µg/$318
AREG / Amphiregulin Protein - 12.5% SDS-PAGE of human AREG stained with Coomassie Blue
Select
Wheat Germ Extract
GST
54.3 kDa
10 µg/$479; 25 µg/$670
AREG / Amphiregulin Protein
Select
E. coli
None
Biologically active
11.3 kDa
10 µg/$282; 100 µg/$503; 500 µg/$1,058
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
11.4kD
10 µg/$255; 50 µg/$343; 500 µg/$1,585; 1 mg/$2,157
AREG / Amphiregulin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
AREG / Amphiregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
27.7 kDa
100 µg/$494
AREG / Amphiregulin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
27.7 kDa
20 µg/$150
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
~11.5 kDa
15 µg/$258; 1 mg/$1,526
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
11.4 kDa
10 µg/$255; 50 µg/$339
AREG / Amphiregulin Protein
Select
E. coli
GST, N-terminus + His, C-terminus
55.3 kDa
50 µg/$419
AREG / Amphiregulin Protein - Recombinant Amphiregulin By SDS-PAGE
Select
E. coli
His-GST
54.8 kDa
10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334
AREG / Amphiregulin Protein - Recombinant  Amphiregulin By SDS-PAGE
Select
E. coli
His-T7
20.4 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
AREG / Amphiregulin Protein - Recombinant  Amphiregulin By SDS-PAGE
Select
E. coli
His-GST
40.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
AREG / Amphiregulin Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
Select
E. coli
6His, N-terminus
14-16 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Viewing 1-16 of 16 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).