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AREG / Amphiregulin

amphiregulin

AREG / Amphiregulin is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions.

Gene Name: amphiregulin
Synonyms: AREG, Amphiregulin, CRDGF, SDGF
Target Sequences: NM_001657 NP_001648.1 P15514

Publications (2)

1
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis. Maximilian Strunz , Lukas M Simon , Meshal Ansari, Jaymin J Kathiriya, Ilias Angelidis, Christoph H Mayr, George Tsidiridis, Marius Lange, Laura F Mattner, Min Yee, Paulina Ogar, Arunima Sengupta, Igor Kukhtevich, Robert Schneider, Zhongming Zhao, Carola Voss, Tobias Stoeger, Jens H L Neumann, Anne Hilgendorff, Jürgen Behr, Michael O'Reilly, Mareike Lehmann, Gerald Burgstaller, Melanie Königshoff, Harold A Chapman, Fabian J Theis, Herbert B Schiller. Nature communications. 2020 July;11:3559. [Full Text Article] [PubMed:32678092] [PMC:PMC7366678] Related Antibodies: LS-B13911.
2
DDX3 modulates the tumor microenvironment via its role in endoplasmic reticulum-associated translation. Hung-Hsi Chen, Hsin-I Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn. iScience. 2021 Sep;24:103086. [Full Text Article] [PubMed:34568799] [PMC:PMC8449240]

☰ Filters
Antibodies (76)
ELISA Kits (40)
Proteins (16)
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Sandwich (29)
Sandwich CLIA (7)
AREG / Amphiregulin (132)
Human (68)
Mouse (25)
Rat (31)
Bovine (10)
Chicken (1)
Cow (8)
Guinea pig (1)
Monkey (1)
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rabbit (50)
mouse (26)
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monoclonal mc (25)
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PE Conjugated (7)
Unconjugated (22)
aa20-100 (16)
aa27-247 (8)
aa97-243 (8)
aa91-140 (4)
91-140 aa, Internal (1)
No (130)
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Biologically active (4)
AREG / Amphiregulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AREG / Amphiregulin Rabbit anti-Human Polyclonal (aa20-100) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
AREG / Amphiregulin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
16.46 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$534
AREG / Amphiregulin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
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HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
15~20 kDa (SDS-PAGE)
50 µg/$296; 10 µg/$253
AREG / Amphiregulin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Rat
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$911
AREG / Amphiregulin ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
11.3 kDa
10 µg/$268; 50 µg/$349
AREG / Amphiregulin ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AREG / Amphiregulin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Human
1.37 - 1000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$851
AREG / Amphiregulin Protein - BALB/3T3 cell proliferation induced by mouse amphiregulin.
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E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 98 amino acid recombinant protein has a predicted molecular mass of approximately 11.3 kD. The DTT-reduced and non-reduced protein migrate at approximately 16 kD and by SDS-PAGE. The N-terminal amino acid is Ser.
10 µg/$268; 25 µg/$318
AREG / Amphiregulin Antibody - 1:100 staining rat heart tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
AREG / Amphiregulin Antibody - Western blot analysis of extracts of various cell lines, using AREG antibody.
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
AREG / Amphiregulin Antibody - AREG monoclonal antibody (M06), clone 3E4. Western Blot analysis of AREG expression in human pancreas.
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AREG / Amphiregulin Mouse anti-Human Monoclonal (3E4) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
AREG / Amphiregulin Antibody - Western Blot; Sample: Recombinant AREG, Human.
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AREG / Amphiregulin Mouse anti-Human Monoclonal Antibody
Rat, Human
WB
Unconjugated
100 µl/$295; 200 µl/$331; 500 µl/$451; 1 ml/$511; 2 ml/$648; 5 ml/$1,099
AREG / Amphiregulin Antibody - AREG / Amphiregulin antibody Western blot of ACHN lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AREG / Amphiregulin Rabbit anti-Human Polyclonal (aa91-140) Antibody
Human
WB
Unconjugated
100 µl/$424
AREG / Amphiregulin Antibody - Immunohistochemistry of paraffin-embedded human breast cancer tissue using AREG Antibody at dilution of 1:100
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
AREG / Amphiregulin ELISA Kit
Select
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$699
AREG / Amphiregulin ELISA Kit
Select
Sandwich
96-Well Microplate
Rabbit
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$656
AREG / Amphiregulin Protein - 12.5% SDS-PAGE of human AREG stained with Coomassie Blue
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Wheat Germ Extract
GST
54.3 kDa
10 µg/$479; 25 µg/$670
AREG / Amphiregulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$624
AREG / Amphiregulin Antibody - Western blot analysis of Amphiregulin using anti-Amphiregulin antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 50ug of sample under reducing conditions. Lane 1: rat brain tissue lysates,Lane 2: mouse brain tissue lysates. After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Amphiregulin antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for Amphiregulin at approximately 41KD. The expected band size for Amphiregulin is at 28KD.
Select
AREG / Amphiregulin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AREG / Amphiregulin Antibody - Anti-Human Amphiregulin Western Blot Unreduced
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AREG / Amphiregulin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$356; 100 µg/$396
AREG / Amphiregulin Antibody - Western blot testing of 1) rat brain and 2) mouse brain lysate with Amphiregulin antibody at 0.5ug/ml. Molecular weight: 28 kDa (non-glycosylated), ~50 kDa (glycosylated pro form), ~43 kDa (predominant glycosylated soluble form) as well as other, smaller, soluble and membrane bound forms.
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AREG / Amphiregulin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
ELISA, WB
Unconjugated
100 µg/$575
Viewing 1-25 of 132 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).