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Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency.
Gene Name: | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 |
Synonyms: | ARAP2, Centaurin, delta 1, Cnt-d1, Centaurin-delta-1, CENTD1, KIAA0580, PARX, Protein PARX |
Target Sequences: | AB011152 BAA25506.2 Q8WZ64 |
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