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ARA9 / AIP

aryl hydrocarbon receptor interacting protein

ARA9 / AIP is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.

Gene Name:	aryl hydrocarbon receptor interacting protein
Synonyms:	AIP, FKBP16, Immunophilin homolog ARA9, HBV X-associated protein 2, XAP2, ARA9, FKBP37, SMTPHN, XAP-2
Target Sequences:	NM_003977 NP_003968.3 O00170

Publications (12)

Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. Petrulis JR, Hord NG, Perdew GH. The Journal of biological chemistry. 2000 275:37448-53. [PubMed:10986286]

The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. Hollingshead BD, Petrulis JR, Perdew GH. The Journal of biological chemistry. 2004 279:45652-61. [PubMed:15322122]

Role of endogenous XAP2 protein on the localization and nucleocytoplasmic shuttling of the endogenous mouse Ahb-1 receptor in the presence and absence of ligand. Pollenz RS, Wilson SE, Dougherty EJ. Molecular pharmacology. 2006 70:1369-79. [PubMed:16835354]

Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D'Innocenzo E, Barlier A, Giangaspero F, Esposito V, Ventura L, Arcella A, Theodoropoulou M, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Gulino A, Cantore G, Aless. Endocrine-related cancer. 2009 16:1029-43. (IHC-P; Human) [PubMed:19556287]

The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. Helivaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Mkinen M, Aaltonen LA, Karhu A. The American journal of pathology. 2009 175:2501-7. (WB; Mouse, Human, Rat) [PubMed:19850893] [PMC:PMC2789606]

Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis. Toledo RA, Mendonca BB, Fragoso MC, Soares IC, Almeida MQ, Moraes MB, Loureno DM, Alves VA, Bronstein MD, Toledo SP. Clinics (So Paulo, Brazil). 2010 65:407-15. (IHC-P; Human) [PubMed:20454499] [PMC:PMC2862671]

Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. Kang BH, Xia F, Pop R, Dohi T, Socolovsky M, Altieri DC. The Journal of biological chemistry. 2011 286:16758-67. (WB; Mouse, Human) [PubMed:21454573] [PMC:PMC3089518]

The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor . Cai W, Kramarova TV, Berg P, Korbonits M, Pongratz I. PloS one. 2011 6:e25201. (WB, IP, ChrIP; Human) [PubMed:21984905] [PMC:PMC3184960]

Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A, Schulz S, Ansorge O, Karavitaki N, Carlsen E, Wass JA, Grossman AB, Korbonits M. The Journal of clinical endocrinology and metabolism. 2012 97:E1411-20. (IHC, WB; Human, Rat) [PubMed:22659247]

MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro. Trivellin G, Butz H, Delhove J, Igreja S, Chahal HS, Zivkovic V, McKay T, Patcs A, Grossman AB, Korbonits M. American journal of physiology. Endocrinology and metabolism. 2012 303:E708-19. (WB; Human, Rat) [PubMed:22811466]

-Catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM. Biochimica et biophysica acta. 2012 1830:2509-2516. (WB; Human) [PubMed:23174221]

Markers of proliferation and invasiveness in somatotropinomas. Baldys-Waligorska A, Wierzbicka I, Sokolowski G, Adamek D, Golkowski F. Endokrynologia Polska. 2018 69:182-189. [Full Text Article] [PubMed:29334118] Related Antibodies: LS-B227.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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