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AQR
aquarius intron-binding spliceosomal factor
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
| Gene Name: | aquarius intron-binding spliceosomal factor |
| Synonyms: | AQR, Aquarius homolog (mouse), IBP160, FSAP164, KIAA0560 |
| Target Sequences: | AB011132 BAA25486.3 O60306 |
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