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AQP3 / Aquaporin 3

aquaporin 3 (Gill blood group)

Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.

Gene Name: aquaporin 3 (Gill blood group)
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP3, Aquaporin 3 (GIL blood group), Aquaglyceroporin-3, AQP-3, Aquaporin 3, Aquaporin 3 (Gill blood group), Aquaporin-3, GIL
Target Sequences: NM_004925 NP_004916.1 Q92482

Publications (6)

1
SOX2 regulates acinar cell development in the salivary gland. Emmerson E, May AJ, Nathan S, Cruz-Pacheco N, Lizama CO, Maliskova L, Zovein AC, Shen Y, Muench MO, Knox SM. eLife. 2017 5: (IF; Mouse, Human) [Full Text Article] [PubMed:28623666] [PMC:PMC5498133] Related Antibodies: LS-B8185.
2
Expression and clinical significance of aquaglyceroporins in human hepatocellular carcinoma. Chen XF, Li CF, Lü L, Mei ZC. Molecular medicine reports. 2016 June;13:5283-9. [Full Text Article] [PubMed:27121567] Related Antibodies: LS-B8185.
3
Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. EMBO molecular medicine. 2018 March;10:pii: e8051. [Full Text Article] [PubMed:29335337] [PMC:PMC5840548] Related Antibodies: LS-B8185.
4
Oleoylethanolamine and palmitoylethanolamine modulate intestinal permeability in vitro via TRPV1 and PPARa. Karwad MA, Macpherson T, Wang B, Theophilidou E, Sarmad S, Barrett DA, Larvin M, Wright KL, Lund JN, O'Sullivan SE. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 February;31:469-481. [Full Text Article] [PubMed:27623929]
5
Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Daniel G Couch, Hollie Cook, Catherine Ortori, Dave Barrett, Jonathan N Lund, Saoirse E O'Sullivan. Inflammatory bowel diseases. 2019 May;25:1006-1018. [Full Text Article] [PubMed:31054246]
6
Aquaporin-3 re-expression induces differentiation in a phospholipase D2-dependent manner in aquaporin-3-knockout mouse keratinocytes. Vivek Choudhary, Lawrence O Olala, Haixia Qin, Inas Helwa, Zhi-Qiang Pan, Ying-Ying Tsai, Michael A Frohman, Ismail Kaddour-Djebbar, Wendy B Bollag. The Journal of investigative dermatology. 2015 Feb;;135:499-507. [Full Text Article] [PubMed:25233074] [PMC:PMC7278525] Related Antibodies: LS-B8185.
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Proteins (3)
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AQP3 / Aquaporin 3 (3)
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AQP3 / Aquaporin 3 Protein - Purified recombinant protein AQP3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
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31.4 kDa
20 µg/$1,107
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31.4 kDa
20 µg/$150
AQP3 / Aquaporin 3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).