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AQP2 / Aquaporin 2

aquaporin 2 (collecting duct)

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Gene Name: aquaporin 2 (collecting duct)
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP2, AQP-CD, ADH water channel, Aquaporin 2 (collecting duct), AQP-2, Aquaporin 2, Aquaporin-CD, Aquaporin-2, Water-channel aquaporin 2, WCH-CD
Target Sequences: NM_000486 NP_000477.1 P41181

Publications (9)

1
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA. The Journal of biological chemistry. 2008 283:24617-27. [PubMed:18606813] [PMC:PMC2528999]
2
Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Moeller HB, Knepper MA, Fenton RA. Kidney international. 2009 75:295-303. [PubMed:18843259] [PMC:PMC3502047]
3
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2441-6. [PubMed:19190182] [PMC:PMC2650175]
4
Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear. Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M. Acta oto-laryngologica. 2012 132:807-13. (ICC, IHC; Mouse) [PubMed:22768909]
5
Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus. Trimpert C, van den Berg DT, Fenton RA, Klussmann E, Deen PM. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:4389-97. (WB, DB; Dog) [PubMed:22778181]
6
Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Journal of the American Society of Nephrology : JASN. 2012 23:1879-90. [PubMed:22997254] [PMC:PMC3482734]
7
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats--species differences and technical considerations. Nowik M, Kampik NB, Mihailova M, Eladari D, Wagner CA. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011 26:1059-72. (WB; Rat) [Full Text Article] [PubMed:21220937]
8
Aquaporin-2 plays an important role in water transportation through the bladder wall in rats. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Akihide Hirayama, Nobumichi Tanaka, Kiyohide Fujimoto. Neurourology and urodynamics. 2018 November;37:2434-2440. [Full Text Article] [PubMed:29797427] Related Antibodies: LS-C312893.
9
Sodium plays an important role in the absorption of intravesical fluid. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto. Lower urinary tract symptoms. 2021 Janurary;13:177-182. [Full Text Article] [PubMed:32410367] Related Antibodies: LS-C312893.
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AQP2 / Aquaporin 2 (78)
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AQP2 / Aquaporin 2 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Sheep, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
AQP2 / Aquaporin 2 Antibody - AQP2 / Aquaporin 2 antibody. IHC(P): Rat Kidney Tissue.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (aa245-260) Antibody
Mouse, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
AQP2 / Aquaporin 2 Antibody - Anti-AQP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
AQP2 / Aquaporin 2 Antibody - Staining of mpkCCD cell line.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AQP2 / Aquaporin 2 Rabbit anti-Rat Polyclonal (aa200-300) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
0.1 ml/$386
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
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AQP2 / Aquaporin 2 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Sheep, Rat, Human
ELISA, WB
Unconjugated
50 µg/$513; 100 µg/$832
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AQP2 / Aquaporin 2 Rabbit anti-Mouse Polyclonal (N-Terminus) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
50 µg/$1,054
AQP2 / Aquaporin 2 Antibody - Immunohistochemistry of AQP2 in human kidney tissue with AQP2 antibody at 5 µg/mL.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
AQP2 / Aquaporin 2 Antibody
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AQP2 / Aquaporin 2 Rabbit anti-Rat Polyclonal (pSer269) Antibody
Mouse, Dog, Bovine, Rat
WB
Unconjugated
100 µl/$469
AQP2 / Aquaporin 2 Antibody - Western blot of AQP2 antibody
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (200-280 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
AQP2 / Aquaporin 2 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP2 / Aquaporin 2 Protein - 12.5% SDS-PAGE of human AQP2 stained with Coomassie Blue
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Wheat Germ Extract
GST
55.2 kDa
10 µg/$479; 25 µg/$670
AQP2 / Aquaporin 2 Antibody - Aquaporin 2 antibody IHC-paraffin. IHC(P): Mouse Kidney Tissue.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (aa241-271) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
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AQP2 / Aquaporin 2 Rabbit anti-Rat Polyclonal (C-Terminus) (Biotin) Antibody
Rat
ELISA, IF, IHC, WB
Biotin Conjugated
50 µg/$896
AQP2 / Aquaporin 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using Aquaporin 2 (Phospho-Ser256) Antibody. The picture on the right is blocked with the phospho peptide.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (pSer256) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
AQP2 / Aquaporin 2 Antibody - Western blot of recombinant AQP2 / Aquaporin 2.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal (aa177-271) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
AQP2 / Aquaporin 2 Antibody - AQP2 / Aquaporin-2 antibody Western blot of Mouse Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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AQP2 / Aquaporin 2 Rabbit anti-Mouse Polyclonal (aa161-210) (Biotin) Antibody
Mouse, Dog, Guinea pig, Rat, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
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AQP2 / Aquaporin 2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, IF, IHC, WB
Unconjugated
100 µg/$832
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AQP2 / Aquaporin 2 Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Rat
ELISA, IF, IHC, WB
Unconjugated
100 µl/$801
AQP2 / Aquaporin 2 Antibody - Immunohistochemistry of paraffin-embedded Mouse kidney using AQP2 Polyclonal Antibody at dilution of 1:100 (40x lens).
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AQP2 / Aquaporin 2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
AQP2 / Aquaporin 2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
Viewing 1-25 of 78 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).