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DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
Gene Name: | aprataxin |
Synonyms: | APTX, AOA1, AXA1, EAOH, EOAHA, FHA-HIT, AOA, Aprataxin |
Target Sequences: | NM_017692 NP_060162.1 Q7Z2E3 |
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