APPL2

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

APPL2 is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

APPL2 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human APPL2 Protein (Recombinant GST) (Full Length) - LS-G34225

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human APPL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90853

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$150

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Human APPL2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71882

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

20 µg/$1,107

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Human APPL2 Protein (Recombinant GST, N-terminus) (aa174-273) - LS-G62667

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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APPL2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G111944

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.3 kDa

Price:

100 µg/$494

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