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APP / Beta Amyloid Precursor
amyloid beta (A4) precursor protein
Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity (By similarity). Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu2+ ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.
| Gene Name: | amyloid beta (A4) precursor protein |
| Family/Subfamily: | Amyloid precursor protein , Not assigned-Other |
| Synonyms: | APP, ABPP, A4, ABETA, AD1, Alzheimer disease, Amyloid beta, Beta-amyloid peptide, APPI, Beta amyloid, CVAP, AAA, PN2, PreA4, Amyloid beta A4 protein, Peptidase nexin-II, CTFgamma, PN-II, Protease nexin-II |
| Target Sequences: | NM_000484 NP_000475.1 P05067 |
Publications (3)
1
Platelets are responsible for the accumulation of ß-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis. Kucheryavykh LY, Dávila-Rodríguez J, Rivera-Aponte DE, Zueva LV, Washington AV, Sanabria P, Inyushin MY. Brain research bulletin. 2017 January;128:98-105. (Human)
[Full Text Article]
[PubMed:27908798]
[PMC:PMC5205543]
Related Antibodies: LS-C181965.
2
Amyloid Beta Peptide Is Released during Thrombosis in the Skin. Kucheryavykh LY, Kucheryavykh YV, Washington AV, Inyushin MY. International journal of molecular sciences. 2018 June;19:pii: E1705. (Human)
[Full Text Article]
[PubMed:29890636]
[PMC:PMC6032379]
Related Antibodies: LS-C181965.
3
Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice. Sandro Alves, Guillaume Churlaud, Mickael Audrain, Kristin Michaelsen-Preusse, Romain Fol, Benoit Souchet, Jérôme Braudeau, Martin Korte, David Klatzmann, Nathalie Cartier. Brain : a journal of neurology. 2017 March;140:826-842. [Full Text Article]
[PubMed:28003243]
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APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (aa18-289) (J4H9) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (MOAB-2) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (Biotin) (MOAB-2) Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, IP, WB
Biotin Conjugated
0.1 ml/$416
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (DY488) (MOAB-2) Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, IP, WB
DY488 Conjugated
0.1 ml/$416
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$585
Sandwich
96-Well Microplate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
E. coli
His
31.2 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (OTI9E2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
Neuroscience
APP / Beta Amyloid Precursor Goat anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (Pyro-Glu11) Antibody
Human, Primate
ELISA, IF, IHC, WB
Unconjugated
50 µg/$567
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (pThr743) Antibody
Chicken, Zebrafish, Pig, Rat, Mouse, Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$315
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (aa737-751) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µg/$695
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (OTI7G9) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
APP / Beta Amyloid Precursor Sheep anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Primate, Human
ELISA, WB
Unconjugated
50 µg/$567
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (aa18-249) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (pThr743/Thr668) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (aa17-25) (Biotin) (3B7) Antibody
Human
ELISA
Biotin Conjugated
100 µg/$392
APP / Beta Amyloid Precursor Mouse anti-Human Monoclonal (aa11-16) (Biotin) (5E11) Antibody
Human
ELISA
Biotin Conjugated
100 µg/$392
APP / Beta Amyloid Precursor Rabbit anti-Human Polyclonal (aa29-61) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$585
293T Cells
Myc-DDK (Flag)
83 kDa
20 µg/$150
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