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Apolipoprotein A-V

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages.

Gene Name: Apolipoprotein A-V
Synonyms: APOA5, Apo-AV, APOAV, Apolipoprotein A5, Apo-A5, Apolipoprotein A-V, RAP3, ApoA-V
Target Sequences: NM_052968 NP_443200.2 Q6Q788

Publications (4)

1
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM. Science (New York, N.Y.). 2001 294:169-73. [PubMed:11588264]
2
Dietary protein restriction reduces circulating VLDL triglyceride levels via CREBH-APOA5-dependent and -independent mechanisms. Treviño-Villarreal JH, Reynolds JS, Bartelt A, Langston PK, MacArthur MR, Arduini A, Tosti V, Veronese N, Bertozzi B, Brace LE, Mejia P, Trocha K, Kajitani GS, Longchamp A, Harputlugil E, Gathungu R, Bird SS, Bullock AD, Figenshau RS, Andriole GL, Thompson A, Heeren J, Ozaki CK, Kristal BS, Fontana L, Mitchell JR. JCI insight. 2018 November;3:pii: 99470. [Full Text Article] [PubMed:30385734] [PMC:PMC6238732]
3
Lipoprotein size is a main determinant for the rate of hydrolysis by exogenous LPL in human plasma. Oleg Kovrov, Fredrik Landfors, Valeria Saar-Kovrov, Ulf Näslund, Gunilla Olivecrona. Journal of lipid research. 2022 Jan;;63:100144. [Full Text Article] [PubMed:34710432] [PMC:PMC8953621]
4
Postprandial metabolism of apolipoproteins B48, B100, C-III, and E in humans with APOC3 loss-of-function mutations. Marja-Riitta Taskinen, Elias Björnson, Niina Matikainen, Sanni Söderlund, Joel Rämö, Mari-Mia Ainola, Antti Hakkarainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Per-Olof Bergh, Marcus Henricsson, Stefano Romeo, Martin Adiels, Samuli Ripatti, Markku Laakso, Chris J Packard, Jan Borén. JCI insight. 2022 October;7: [Full Text Article] [PubMed:36040803] [PMC:PMC9675484]
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ELISA Kits (23)
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Apolipoprotein A-V (23)
Human (8)
Mouse (4)
Rat (6)
Chicken (1)
Monkey (1)
Pig (1)
Rabbit (1)
Sheep (1)
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DevKit DuoPlus (3)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (17)
Antibody Pair and Standard (3)
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Yes (2)
Cell Culture Supernatants (6)
Cell Lysates (6)
Cell Supernatant (1)
Plasma (18)
Serum (18)
Tissue Homogenates (9)
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$715
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$784
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$495
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Human
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$750
Apolipoprotein A-V ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$656
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$565
Apolipoprotein A-V ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$656
Apolipoprotein A-V ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$691
Apolipoprotein A-V ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,254; 1000 Wells/$1,867
Apolipoprotein A-V ELISA Kit
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Development Kit
Antibody Pair and Standard
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,305; 1000 Wells/$1,952
Apolipoprotein A-V ELISA Kit
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Development Kit
Antibody Pair and Standard
Human
2.5 - 160 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
500 Wells/$1,229; 1000 Wells/$1,826
Apolipoprotein A-V ELISA Kit
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Competitive EIA
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
Apolipoprotein A-V ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$897
Apolipoprotein A-V ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Supernatant, Plasma, Serum
1 Plate/$528
Apolipoprotein A-V ELISA Kit
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Sandwich
96-Well Microplate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$565
Apolipoprotein A-V ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
Apolipoprotein A-V ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$805
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).