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Apolipoprotein (Apo-) A-II is the second most abundant protein of the high density lipoprotein particles. The apo-A-II gene consists of 4 exons and 3 introns. The four exons encode the 5' untranslated region, pre-peptide, a short N-terminal domain and a C-terminal domain composed of a variable number of lipid-binding amphipathic helices. Familial apo-A-II deficiency may result from a splice-junction alteration which blocks splicing of intron 3 from the primary transcript and result the formation of a non-functional mRNA.
Gene Name: | Apolipoprotein A-II |
Synonyms: | APOA2, Apo-AII, ApoAII, ApoA-II, Apolipoprotein A-II, Apolipoprotein A2, Apolipoprotein A II |
Target Sequences: | NM_001643 NP_001634.1 P02652 |
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