APOER2 / LRP8

low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

APOER2 / LRP8 (8)

Publications

No (8)

Tag

GST, N-terminus (1)

His (1)

His-GST (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human APOER2 / LRP8 Protein (Recombinant His-GST) (aa696-941) - LS-G15168

Source:

E. coli

Tag:

His-GST

Molecular Weight:

59.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human APOER2 / LRP8 Protein (Recombinant His) (aa52-153) - LS-G141083

Source:

E. coli

Sequence Length:

101 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

11.22 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human APOER2 / LRP8 Protein (Recombinant GST, N-terminus) (aa83-170) - LS-G60603

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APOER2 / LRP8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74552

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.13 kDa

Price:

20 µg/$150

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Human APOER2 / LRP8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74553

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

20 µg/$215

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Human APOER2 / LRP8 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64965

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

74.4 kDa

Price:

20 µg/$1,107

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APOER2 / LRP8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121244

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

99.13 kDa

Price:

100 µg/$494

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APOER2 / LRP8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112408

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

78.3 kDa

Price:

100 µg/$710

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