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APOER2 / LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
| Gene Name: | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor |
| Synonyms: | LRP8, Apolipoprotein E receptor 2, APOER2, MCI1, HSZ75190, ApoE receptor 2, LRP-8 |
| Target Sequences: | NM_004631 NP_004622.2 Q14114 |
Publications (1)
1
Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence, and Inflammation via Toll-like Receptor 4, Reactive Oxygen Species, and p38 MAPK Signaling. Mancy Tong, Teimur Kayani, Deidre M Jones, Jane E Salmon, Shannon Whirledge, Lawrence W Chamley, Vikki M Abrahams. Arthritis & rheumatology (Hoboken, N.J.). 2022 June;74:1001-1012. [Full Text Article]
[PubMed:35044724]
[PMC:PMC9156528]
Related Antibodies: LS-B169.
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APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa863-963) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
APOER2 / LRP8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Chicken, Mouse, Human
ICC, IF, IHC, IHC-P, WB
Biotin Conjugated
0.1 ml/$416
APOER2 / LRP8 Rabbit anti-Human Polyclonal (C-Terminus) (DY650) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY650 Conjugated
0.1 ml/$416
APOER2 / LRP8 Rabbit anti-Human Polyclonal (C-Terminus) (DY488) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY488 Conjugated
0.1 ml/$416
APOER2 / LRP8 Rabbit anti-Human Polyclonal (C-Terminus) (DY550) Antibody
Human
ICC, IF, IHC, IHC-P, WB
DY550 Conjugated
0.1 ml/$416
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa800-900) Antibody
Chicken, Bovine, Mouse, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa395-444) (Biotin) Antibody
Human
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa395-444) (FITC) Antibody
Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
APOER2 / LRP8 Mouse anti-Human Monoclonal (6F6B6) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
APOER2 / LRP8 Rabbit anti-Human Polyclonal (420-500 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
APOER2 / LRP8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
APOER2 / LRP8 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa500-545) Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
E. coli
His-GST
59.3 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
APOER2 / LRP8 Rabbit anti-Human Polyclonal Antibody
Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa934-963) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa441-490) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
E. coli
101 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
11.22 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
APOER2 / LRP8 Mouse anti-Human Monoclonal (7G12E2) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$459
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa934-963) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa934-963) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
APOER2 / LRP8 Rabbit anti-Human Polyclonal (aa934-963) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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