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APOE / Apolipoprotein E
apolipoprotein E
Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
| Gene Name: | apolipoprotein E |
| Synonyms: | APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG |
| Target Sequences: | NM_000041 NP_000032.1 P02649 |
Publications (2)
1
A proteomic approach for the diagnosis of bacterial meningitis. Jesse S, Steinacker P, Lehnert S, Sdzuj M, Cepek L, Tumani H, Jahn O, Schmidt H, Otto M. PloS one. 2010 5:e10079. (WB)
[PubMed:20386697]
[PMC:PMC2851643]
2
Longterm Increased S100B Enhances Hippocampal Progenitor Cell Proliferation in a Transgenic Mouse Model. Leticia Rodrigues, Krista Minéia Wartchow, Michael Buchfelder, Diogo Onofre Souza, Carlos-Alberto Gonçalves, Andrea Kleindienst. International journal of molecular sciences. 2022 August;23: [Full Text Article]
[PubMed:36076994]
[PMC:PMC9455494]
☰ Filters
Products
Proteins
(20)
Type
Over-Expression Cell Culture Supernatant
(1)
Over-Expression Lysate
(3)
Recombinant
(16)
Target
APOE / Apolipoprotein E
(20)
Application
SDS-PAGE
(1)
Publications
No
(20)
Tag
10His, N-terminus + Myc, C-terminus
(1)
10His-B2M, N-terminus + Myc, C-terminus
(1)
10His-SUMO, N-terminus + Myc, C-terminus
(1)
6His, C-terminus
(4)
6His, N-terminus
(4)
GST-6His, N-terminus
(1)
His, N-Terminal
(1)
His,N-terminus + GST
(1)
His-S
(1)
His-T7
(1)
Myc-DDK (Flag)
(3)
TRX-His, N-terminus
(1)
Species
Dog
(1)
Human
(9)
Mouse
(5)
Rabbit
(3)
Rat
(1)
Source
293T Cells
(1)
E. coli
(9)
HEK 293 Cells
(6)
Human Cells
(1)
Mammalian Cells
(2)
Yeast
(1)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(4)
HEK 293 Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3kD
10 µg/$218; 50 µg/$240; 500 µg/$343; 1 mg/$409
Yeast
6His, N-terminus
35.9 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
HEK 293 Cells
His, N-Terminal
~37 kDa
10 µg/$289; 50 µg/$360
E. coli
6His, N-terminus
38 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
E. coli
His,N-terminus + GST
49.6 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
E. coli
GST-6His, N-terminus
50.0 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35kD
10 µg/$288; 50 µg/$516; 500 µg/$1,262; 1 mg/$1,627
E. coli
10His, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
E. coli
His-T7
23.0 kDa
10 µg/$259; 50 µg/$331; 100 µg/$482; 200 µg/$602; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723
HEK 293 Cells
Myc-DDK (Flag)
34.2 kDa
20 µg/$1,107
293T Cells
Myc-DDK (Flag)
36.15 kDa
20 µg/$150
HEK 293 Cells
Myc-DDK (Flag)
36.15 kDa
100 µg/$494
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.3 kDa
10 µg/$220; 50 µg/$240
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
35.0 kDa
10 µg/$286; 50 µg/$507
E. coli
TRX-His, N-terminus
SDS-PAGE
The recombinant human APOE/Trx fusion protein consisting of 458 amino acids and has a calculated molecular mass of 51.3 kDa. It migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
1 mg/$519; 100 µg/$271
E. coli
His-S
23.7 kDa
10 µg/$292; 50 µg/$512; 100 µg/$817; 200 µg/$1,018; 1 mg/$2,168; 500 µg/$1,690; 5 mg/$3,571; 2 mg/$2,359
HEK 293 Cells
6His, N-terminus
37 kDa
100 µg/$298
HEK 293 Cells
6His, N-terminus
37 kDa
200 µl/$283
E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
E. coli
10His-B2M, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$598; 20 µg/$405
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product results
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