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Apolipoprotein (apo) C-II is a necessary cofactor for the activation of lipoprotein lipase, the enzyme that hydrolyzes triglycerides in plasma and transfers the fatty acids to tissues. ApoC-II gene contains 3338 nucleotides with 3 introns, of 2391, 167, and 298 bases, and 4 exons. The first intron is located within the 5-prime untranslated region of the gene and contains 4 Alu sequences. The second intron interrupts the codon specifying amino acid -11 of the signal peptide. The third and last intron is composed almost entirely of a novel 37 bp minisatellite, which is repeated five and a partial times (positions 3396-3604). This minisatellite is found in about 60 locations, all on the long arm of chromosome 19, and seems to be highly conserved. There are three polyadenylation signals, two of which are located after the mRNA end.
Gene Name: | apolipoprotein C-II |
Synonyms: | APOC2, Apolipoprotein C-II, APO-CII, Apolipoprotein C2, APOC-II |
Target Sequences: | NM_000483 NP_000474.2 P02655 |
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