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APOBEC3H

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

Gene Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H
Synonyms: APOBEC3H, APOBEC-related protein 10, ARP10, ARP-10
Target Sequences: Q6NTF7 Q6NTF7

Publications (1)

1
Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis. Konstantinos Evangelou, Dimitris Veroutis, Koralia Paschalaki, Periklis G Foukas, Nefeli Lagopati, Marios Dimitriou, Angelos Papaspyropoulos, Bindu Konda, Orsalia Hazapis, Aikaterini Polyzou, Sophia Havaki, Athanassios Kotsinas, Christos Kittas, Athanasios G Tzioufas, Laurence de Leval, Demetris Vassilakos, Sotirios Tsiodras, Barry R Stripp, Argyris Papantonis, Giovanni Blandino, Ioannis Karakasiliotis, Peter J Barnes, Vassilis G Gorgoulis. The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology. 2022 February;60:2102951. [Full Text Article] [PubMed:35086840] [PMC:PMC8796696] Related Antibodies: LS-C151868.

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Products
Antibodies (7)
Primary (7)
APOBEC3H (7)
Human (7)
Chimpanzee (3)
Gibbon (3)
Monkey (3)
Orangutan (3)
WB (7)
ELISA (1)
IF (1)
Peptide-ELISA (1)
rabbit (6)
mouse (1)
IgG (2)
polyclonal pc (7)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (4)
C-Terminus (4)
No (6)
Yes (1)
APOBEC3H Antibody - APOBEC3H antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC3H Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
APOBEC3H Antibody - APOBEC3H antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC3H Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
WB
HRP Conjugated
100 µl/$469
APOBEC3H Antibody - APOBEC3H antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC3H Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
WB
Biotin Conjugated
100 µl/$469
APOBEC3H Antibody - APOBEC3H antibody Western Blot of Jurkat.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC3H Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Monkey, Chimpanzee, Orangutan, Gibbon
WB
FITC Conjugated
100 µl/$469
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APOBEC3H Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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APOBEC3H Mouse anti-Human Polyclonal Antibody
Human
IF, WB
Unconjugated
50 µg/$705
APOBEC3H Antibody - Western blot analysis of APOBEC3H using A549 whole cells lysates
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APOBEC3H Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).