APOBEC3G / CEM15

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits potent antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

APOBEC3G / CEM15 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human APOBEC3G / CEM15 Protein (Recombinant GST) (Full Length) - LS-G34875

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human APOBEC3G / CEM15 Protein (Recombinant GST, N-terminus) (aa80-181) - LS-G63043

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APOBEC3G / CEM15 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91551

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

20 µg/$150

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Human APOBEC3G / CEM15 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72151

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

20 µg/$1,107

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APOBEC3G / CEM15 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110591

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.2 kDa

Price:

100 µg/$494

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