APOBEC3C

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV), herpes simplex virus 1 (HHV-1) and Epstein-Barr virus (EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

APOBEC3C (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human APOBEC3C Protein (Recombinant GST) (Full Length) - LS-G33344

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

49.2 kDa

Price:

2 µg/$439

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Human APOBEC3C Protein (Recombinant GST, N-terminus) (aa91-190) - LS-G62281

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human APOBEC3C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82358

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

20 µg/$150

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Human APOBEC3C Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68509

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

20 µg/$1,107

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APOBEC3C Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113877

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

22.6 kDa

Price:

100 µg/$494

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Human APOBEC3C Protein (Recombinant GST, N-terminus) (aa1-190) - LS-G57568

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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