APOB / Apolipoprotein B

apolipoprotein B

Apolipoprotein B (ApoB) is the main apolipoprotein of chylomicrons and low density lipoproteins (LDL). The protein occurs in the plasma in 2 main isoforms, apoB-48 and apoB-100. The first is synthesized exclusively by the gut, the second by the liver. The intestinal (B-48) and hepatic (B-100) forms of apoB are coded by a single gene and by a single mRNA transcript larger than 16 kb. The 2 proteins share a common amino terminal sequence. In the ApoB-100 isoform the precursor has 4563 amino acids, and the mature apoB-100 has 4536 amino acid residues. Mature, circulating B-48 is homologous over its entire length (estimated to be between 2130 and 2144 amino acid residues) with the amino-terminal portion of B-100 and contains no sequence from the carboxyl end of B-100. From structural studies, it is thought that apoB-48 represents the amino-terminal 47% of apoB-100 and that the carboxyl terminus of apoB-48 is in the vicinity of residue 2151 of apoB-100. Apolipoprotein B-48 may be the product of an intestinal mRNA with an in-frame UAA stop codon resulting from a C-to-U change in the codon CAA encoding Gln(2153) in apoB-100 mRNA. Since only the sequence that codes B-100 is present in genomic DNA, this presents the possibility of an organ-specific introduction of a stop codon to an mRNA and the change from CAA to UAA of codon 2153 of the message as a unique RNA editing process.

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Products

Proteins (9)

Type

Recombinant (9)

Target

APOB / Apolipoprotein B (9)

Publications

No (9)

Tag

10His, N-terminus (1)

6His, N-terminus (2)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His,N-terminus (1)

His-GST (1)

Species

Human (6)

Mouse (1)

Pig (1)

Rat (1)

Source

E. coli (7)

Wheat Germ Extract (1)

Yeast (1)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (1)

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Mouse APOB / Apolipoprotein B (Recombinant His) (aa3360-3526) - LS-G14627

Source:

E. coli

Tag:

His

Molecular Weight:

19.6 kDa

Price:

10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998

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Human APOB / Apolipoprotein B (Recombinant 6His, N-terminus) (aa3365-3548) - LS-G14619

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

21.4 kDa

Price:

10 µg/$251; 50 µg/$311; 100 µg/$402; 200 µg/$502; 1 mg/$1,365; 500 µg/$1,002; 5 mg/$2,254; 2 mg/$1,523

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Rat APOB / Apolipoprotein B (Recombinant His) (aa3329-3494) - LS-G14623

Source:

E. coli

Tag:

His

Molecular Weight:

21.8 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human APOB / Apolipoprotein B (Recombinant GST, N-terminus) (aa28-127) - LS-G57788

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APOB / Apolipoprotein B (Recombinant 10His, N-terminus) - LS-G137425

Source:

E. coli

Tag:

10His, N-terminus

Molecular Weight:

14.7 kDa

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human APOB / Apolipoprotein B (Recombinant His,N-terminus) (Glu28-Ser127) - LS-G140590

Source:

E. coli

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

13.5 kDa

Price:

10 µg/$344; 50 µg/$584

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Pig APOB / Apolipoprotein B (Recombinant His-GST) (aa331-511) - LS-G14622

Source:

E. coli

Tag:

His-GST

Molecular Weight:

46.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human APOB / Apolipoprotein B (Recombinant His, N-Terminal) (His3365-Glu3548) - LS-G133027

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

21.4kDa

Price:

10 µg/$259; 50 µg/$331; 200 µg/$602; 100 µg/$482; 1 mg/$1,553; 500 µg/$1,156; 5 mg/$2,481; 2 mg/$1,723

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Human APOB / Apolipoprotein B (Recombinant 6His, N-terminus) (aa28-127) - LS-G57116

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

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