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Apoliprotein (apo) A-IV gene contains 3 exons separated by two introns. A sequence polymorphism has been identified in the 3'UTR of the third exon. The primary translation product is a 396-residue preprotein which after proteolytic processing is secreted its primary site of synthesis, the intestine, in association with chylomicron particles. Although its precise function is not known, apo A-IV is a potent activator of lecithin-cholesterol acyltransferase in vitro.
Gene Name: | apolipoprotein A-IV |
Synonyms: | APOA4, Apo-AIV, Apolipoprotein A-IV, Apolipoprotein A4, ApoA-IV |
Target Sequences: | NM_000482 NP_000473.2 P06727 |
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