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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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APLF / PALF
aprataxin and PNKP like factor
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.
| Gene Name: | aprataxin and PNKP like factor |
| Synonyms: | APLF, Aprataxin- and PNK-like factor, APFL, Aprataxin and PNK-like factor, Aprataxin and PNKP like factor, PALF, PNK and APTX-like FHA protein, XRCC1-interacting protein 1, Xip1, C2orf13 |
| Target Sequences: | Q8IW19 Q8IW19 |
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