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Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.
Gene Name: | APAF1 interacting protein |
Synonyms: | APIP, APAF1-interacting protein, APIP2, CGI29, CGI-29, DJ179L10.2, MTRu-1-P dehydratase, APAF1 interacting protein, MMRP19 |
Target Sequences: | NM_015957 NP_057041.2 Q96GX9 |
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