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Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Gene Name: | apoptosis inhibitor 5 |
Synonyms: | API5, AAC11, AAC-11, Antiapoptosis clone 11 protein, API-5, Apoptosis inhibitor 5, FIF, API5L1, Protein XAGL |
Target Sequences: | NM_006595 NP_006586.1 Q9BZZ5 |
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