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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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Customer Service: (800) 227-6666 / (650) 697-3600
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APH1A / APH-1
APH1A gamma secretase subunit
APH1A / APH-1 is a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants.
| Gene Name: | APH1A gamma secretase subunit |
| Family/Subfamily: | Protease Regulation |
| Synonyms: | APH1A, Aph-1alpha, APH-1, CGI-78, PSF, APH-1A, Gamma-secretase subunit APH-1A |
| Target Sequences: | NM_016022 NP_057106.2 Q96BI3 |
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