APC

Adenomatous Polyposis Coli

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

APC (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7 (3)

Myc-DDK (Flag) (2)

Species

Human (3)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human APC Protein (Recombinant His-T7) (Ala2634-Val2843) - LS-G14885

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.2 kDa

Price:

10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090

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Mouse APC Protein (Recombinant His-T7) (aa2636-2845) - LS-G14889

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.9 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Rat APC Protein (Recombinant His-T7) (aa2634-2842) - LS-G14888

Source:

E. coli

Tag:

His-T7

Molecular Weight:

25.6 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human APC Protein (Recombinant GST, N-terminus) (aa2744-2843) - LS-G57781

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74316

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

311.5 kDa

Price:

20 µg/$215

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APC Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124657

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

311.5 kDa

Price:

100 µg/$710

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