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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
United States
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APBB1 / FE65
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
| Gene Name: | amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) |
| Synonyms: | APBB1, FE65, Adaptor protein FE65a2, Protein Fe65, Stat-like protein, MGC:9072, RIR |
| Target Sequences: | NM_001164 NP_001155.1 O00213 |
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