APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

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Products

Antibodies (68)

Type

Primary (68)

Target

APAF1 / APAF-1 (68)

Reactivity

Human (59)

Mouse (35)

Rat (21)

C. elegans (4)

Gerbil (2)

Mammal (4)

Monkey (1)

Application

IHC (27)

IHC-Fr (1)

IHC-P (15)

WB (59)

Flo (2)

ELISA (18)

ICC (5)

IF (5)

IP (11)

Peptide-ELISA (2)

Host

rabbit (60)

mouse (5)

rat (3)

Product Group

IHCPlus (3)

Isotype

IgG (30)

IgG1 (2)

IgG1,k (1)

IgG2a,k (3)

IgG2b (2)

Clonality

monoclonal mc (8)

polyclonal pc (60)

Clone

13F11 (1)

18H2 (1)

2E10 (1)

2E12 (1)

2H9A1 (1)

2H9G5 (1)

5C1 (1)

5E11 (1)

Format

APC (2)

APC Conjugated (3)

Biotin Conjugated (5)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

Low Endotoxin (1)

Magnetic beads Conjugated (1)

PE Conjugated (4)

Sepharose Conjugated (1)

Unconjugated (40)

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Epitope

aa31-350 (8)

aa872-1135 (8)

N-Terminus (5)

C-Terminus (2)

aa1-97 (2)

aa12-28 (2)

501-550 aa, Internal (1)

His324 (1)

Internal (1)

Ser320 (1)

aa1-464 (1)

aa1051-1248 (1)

aa289-338 (1)

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Publications

No (68)

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IHC-plus™ APAF1 / APAF-1 Antibody (aa1-464, clone 2E12, Low Endotoxin) LS-B12884

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rat anti-Human Monoclonal (aa1-464) (Low Endotoxin) (2E12) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IHC, IHC-P, IP, WB

Format:

Unconjugated, Low Endotoxin

Price:

50 µg/$460

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APAF1 / APAF-1 Antibody LS-C284

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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APAF1 / APAF-1 Antibody LS-C148201

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Gerbil, Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$386

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APAF1 / APAF-1 Antibody LS-C285

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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IHC-plus™ APAF1 / APAF-1 Antibody (C-Terminus) LS-B3340

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

250 µl/$485

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IHC-plus™ APAF1 / APAF-1 Antibody (aa289-338) LS-B7591

(4.0) Rating

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (aa289-338) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

APAF1 / APAF-1 Antibody (C-Terminus) LS-C351827

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

APAF1 / APAF-1 Antibody (clone 2H9A1) LS-C682621

Antibody:

APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9A1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

APAF1 / APAF-1 Antibody LS-C659197

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

APAF1 / APAF-1 Antibody LS-C800241

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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APAF1 / APAF-1 Antibody (His324) LS-C175921

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (His324) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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APAF1 / APAF-1 Antibody (aa1-97, clone 13F11) LS-C344794

Antibody:

APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (13F11) Antibody

Reactivity:

Mouse, Rat

Applications:

ELISA, ICC, IP, WB

Format:

Unconjugated

Price:

100 µg/$421

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APAF1 / APAF-1 Antibody (aa1-97, clone 18H2) LS-C344795

Antibody:

APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (18H2) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, ICC, IP, WB

Format:

Unconjugated

Price:

100 µg/$421

Select

APAF1 / APAF-1 Antibody LS-C375229

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

APAF1 / APAF-1 Antibody (501-550 aa, Internal) LS-C387145

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

APAF1 / APAF-1 Antibody (clone 2H9G5) LS-C682644

Antibody:

APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9G5) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

APAF1 / APAF-1 Antibody (N-Terminus) LS-C178933

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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APAF1 / APAF-1 Antibody LS-C402084

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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APAF1 / APAF-1 Antibody LS-C69076

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$531

Select

APAF1 / APAF-1 Antibody (N-Terminus) LS-C121385

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

Select

APAF1 / APAF-1 Antibody LS-C358642

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

APAF1 / APAF-1 Antibody LS-C358643

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

APAF1 / APAF-1 Antibody LS-C358645

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Gerbil, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

50 µl/$393

Select

APAF1 / APAF-1 Antibody (aa12-28) LS-C42802

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal (aa12-28) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$518

Select

APAF1 / APAF-1 Antibody LS-C411994

Antibody:

APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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