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APAF1 / APAF-1
apoptotic peptidase activating factor 1
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.
| Gene Name: | apoptotic peptidase activating factor 1 |
| Family/Subfamily: | Apoptosis , Not assigned-Other |
| Synonyms: | APAF1, APAF-1, CED4, KIAA0413 |
| Target Sequences: | NM_013229 NP_037361.1 O14727 |
Publications (1)
1
Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload. da Silva VK, de Freitas BS, Garcia RCL, Monteiro RT, Hallak JE, Zuardi AW, Crippa JAS, Schröder N. Translational psychiatry. 2018 September;8:176. [Full Text Article]
[PubMed:30177808]
[PMC:PMC6120904]
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APAF1 / APAF-1 Rat anti-Human Monoclonal (aa1-464) (Low Endotoxin) (2E12) Antibody
Human
ELISA, ICC, IHC, IHC-P, IP, WB
Unconjugated, Low Endotoxin
50 µg/$460
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC-P, WB
Unconjugated
0.1 mg/$460
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50 µl/$386
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
0.1 mg/$460
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
250 µl/$485
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (aa289-338) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9A1) Antibody
Human
ELISA, Flo, ICC, WB
Unconjugated
100 µl/$459
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (His324) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (13F11) Antibody
Mouse, Rat
ELISA, ICC, IP, WB
Unconjugated
100 µg/$421
APAF1 / APAF-1 Rat anti-Mouse Monoclonal (aa1-97) (18H2) Antibody
Mouse, Human
ELISA, ICC, IP, WB
Unconjugated
100 µg/$421
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$750
HEK 293 Cells
8His, N-terminus
52.6 kDa
100 µg/$298
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (501-550 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
APAF1 / APAF-1 Mouse anti-Human Monoclonal (2H9G5) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
50 µl/$531
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IP, WB
Unconjugated
50 µl/$393
APAF1 / APAF-1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Gerbil, Human
IHC, IP, WB
Unconjugated
50 µl/$393
APAF1 / APAF-1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$564
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