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AP4E1 / Adaptin Epsilon
Adaptor-related Protein Complex 4, Epsilon 1 Subunit
AP4E1 / Adaptin Epsilon is a member of the adaptor complexes large subunit protein family. These proteins are components of the heterotetrameric adaptor protein complexes, which play important roles in the secretory and endocytic pathways by mediating vesicle formation and sorting of integral membrane proteins. The encoded protein is a large subunit of adaptor protein complex-4, which is associated with both clathrin- and nonclathrin-coated vesicles. Disruption of this gene may be associated with cerebral palsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
| Gene Name: | Adaptor-related Protein Complex 4, Epsilon 1 Subunit |
| Synonyms: | AP4E1, AP-4 complex subunit epsilon-1, CPSQ4, Epsilon-adaptin, AP-4-EPSILON, Epsilon subunit of AP-4, SPG51 |
| Target Sequences: | NM_007347 NP_031373.2 Q9UPM8 |
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