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AP1AR
adaptor-related protein complex 1 associated regulatory protein
Necessary for adaptor protein complex 1 (AP-1)-dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/gamma1-adaptin, one of the subunits of the AP-1 adaptor complex. The direct interaction with AP1G1/gamma1-adaptin attenuates the release of the AP-1 complex from membranes. Regulates endosomal membrane traffic via association with AP-1 and KIF5B thus linking kinesin-based plus-end-directed microtubular transport to AP-1-dependent membrane traffic. May act as effector of AP-1 in calcium-induced endo-lysosome secretion. Inhibits Arp2/3 complex function; negatively regulates cell spreading, size and motility via intracellular sequestration of the Arp2/3 complex.
| Gene Name: | adaptor-related protein complex 1 associated regulatory protein |
| Synonyms: | AP1AR, 2C18, Gamma-BAR, GBAR, PRO0971, C4orf16 |
| Target Sequences: | NM_018569 NP_061039.3 Q63HQ0 |
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