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ANXA7 / Annexin VII / SNX

annexin A7

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.

Gene Name: annexin A7
Synonyms: ANXA7, Annexin VII, Annexin-7, SYNEXIN, Annexin A7, ANX7, SNX
Target Sequences: NM_004034 NP_004025.1 P20073

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Products
Proteins (11)
Over-Expression Lysate (4)
Recombinant (6)
ANXA7 / Annexin VII / SNX (11)
No (11)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (6)
Human (9)
293T Cells (2)
E. coli (4)
HEK 293 Cells (4)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (2)
ANXA7 / Annexin VII / SNX Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261; 10 µg/$238; 50 µg/$304; 250 µg/$523
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
50.32kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
ANXA7 / Annexin VII / SNX Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
ANXA7 / Annexin VII / SNX Protein - Purified recombinant protein ANXA7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
50.1 kDa
20 µg/$1,107
ANXA7 / Annexin VII / SNX Protein - Purified recombinant protein ANXA7 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
52.6 kDa
20 µg/$1,107
ANXA7 / Annexin VII / SNX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
50.1 kDa
100 µg/$494
Select
293T Cells
Myc-DDK (Flag)
50.1 kDa
20 µg/$150
ANXA7 / Annexin VII / SNX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.6 kDa
20 µg/$215
ANXA7 / Annexin VII / SNX Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.6 kDa
100 µg/$710
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E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
50.3 kDa
10 µg/$288; 50 µg/$436
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E. coli
None
52.9 kDa
5 µg/$329; 20 µg/$412; 1000 µg/$3,417
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).