ANPEP / CD13

alanyl (membrane) aminopeptidase

ANPEP (CD13) is a broad specificity aminopeptidase involved in the metabolism of biologically active peptides, phagocytosis, and myeloid cell differentiation. It is known to have bactericidal and tumoricidal activity. ANPEP plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. It is thought to be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. ANPEP cleaves antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. It is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. In normal tissue, ANPEP is present on a majority of cells of myeloid origin, including granulocytes, monocytes, mast cells, and GM-progenitor cells. It is also found on fibroblasts, endothelial cells, epithelial cells from renal proximal tubules and intestinal brush border, bone marrow stromal cells, osteoclasts, and cells lining bile duct canaliculi. In cancer and disease, it is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. It is expressed by the majority of AML, CML in myeloid blast crisis, and in a smaller fraction of lymphoid leukemia. It is absent in normal lymphocytes, platelets and erythrocytes. In the case of human coronavirus 229E (HCoV-229E) infection, it serves as receptor for HCoV-229E spike glycoprotein. It also mediates human cytomegalovirus (HCMV) infection. Additionally, it may play a critical role in the pathogenesis of cholesterol gallstone disease.

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Products

Proteins (12)

Type

Recombinant (12)

Target

ANPEP / CD13 (12)

Product Group

Coronavirus Antibodies Proteins cDNAs (12)

SARS-CoV-2 Associated Proteins (12)

Publications

No (12)

Tag

10His, N-terminus + Myc, C-terminus (1)

6His, C-terminus (2)

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (1)

His,C-terminus (1)

His-T7 (3)

Myc-DDK (Flag) (1)

Species

Human (6)

Mouse (3)

Pig (1)

Rat (2)

Source

E. coli (5)

HEK 293 Cells (2)

Human Cells (3)

Wheat Germ Extract (2)

Purification

Purified (5)

Low Endotoxin Level

Low endotoxin level (4)

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Human ANPEP / CD13 Protein (Recombinant 6His, C-terminus) - LS-G145898

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

103.5 kDa

Price:

10 µg/$362; 50 µg/$756

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Rat ANPEP / CD13 Protein (Recombinant 6His-SUMO, N-terminus) (aa33-476) - LS-G56087

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Rat ANPEP / CD13 Protein (Recombinant His-T7) (aa290-533) - LS-G13299

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.3 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse ANPEP / CD13 Protein (Recombinant His-T7) (aa720-961) - LS-G13295

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.8 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181

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Human ANPEP / CD13 Protein (Recombinant GST, N-terminus) (aa858-967) - LS-G57765

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ANPEP / CD13 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G64924

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

106.3 kDa

Price:

20 µg/$1,107

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Mouse ANPEP / CD13 Protein (Recombinant 6His, C-terminus) - LS-G145901

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

103.6 kDa

Price:

10 µg/$362; 50 µg/$756

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Pig ANPEP / CD13 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G136953

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

47.1 kDa

Price:

20 µg/$405; 1 mg/$1,679; 100 µg/$598

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Human ANPEP / CD13 Protein (Recombinant His-T7) (aa581-738) - LS-G24196

Source:

E. coli

Tag:

His-T7

Molecular Weight:

22.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ANPEP / CD13 Protein (Recombinant GST) (Full Length) - LS-G27454

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

135.9 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ANPEP / CD13 Protein (Recombinant His,C-terminus) (Lys69-Lys967) - LS-G140814

Source:

HEK 293 Cells

Tag:

His,C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

104.2 kDa

Price:

50 µg/$977

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Mouse ANPEP / CD13 Protein (Recombinant His) (Lys66-Ser966) - LS-G98051

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

104 kDa

Price:

50 µg/$854

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