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ANO1 / DOG1 / TMEM16A

anoctamin 1, calcium activated chloride channel

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Gene Name:	anoctamin 1, calcium activated chloride channel
Synonyms:	ANO1, Oral cancer overexpressed 2, Transmembrane protein 16A, ORAOV2, Anoctamin-1, DOG1, TAOS2, TMEM16A
Target Sequences:	NM_018043 NP_060513.5 Q5XXA6

Publications (2)

Combined inhibition of MAP kinase and KIT signaling synergistically destabilizes ETV1 and suppresses GIST tumor growth. Ran L, Sirota I, Cao Z, Murphy D, Chen Y, Shukla S, Xie Y, Kaufmann MC, Gao D, Zhu S, Rossi F, Wongvipat J, Taguchi T, Tap WD, Mellinghoff IK, Besmer P, Antonescu CR, Chen Y, Chi P. Cancer discovery. 2015 5:304-15. (IHC; Human) [Full Text Article] [PubMed:25572173] [PMC:PMC4355391]

Suppression of CaMKIIß Inhibits ANO1-Mediated Glioblastoma Progression. Kyoung Mi Sim, Young-Sun Lee, Hee Jin Kim, Chang-Hoon Cho, Gwan-Su Yi, Myung-Jin Park, Eun Mi Hwang, Jae-Yong Park. Cells. 2020 April;9: [Full Text Article] [PubMed:32357567] [PMC:PMC7290681]

ANO1 / DOG1 / TMEM16A Protein - Recombinant Anoctamin 1 By SDS-PAGE

Mouse ANO1 / DOG1 / TMEM16A Protein (Recombinant His-T7) (aa20-239) - LS-G13726

Source:

E. coli

Tag:

His-T7

Molecular Weight:

28.4 kDa

Price:

50 µg/$442; 10 µg/$281; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Products: Proteins

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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