ANK1 / Ankyrin

ankyrin 1, erythrocytic

Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified.

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Proteins (2)

Type

Recombinant (2)

Target

ANK1 / Ankyrin (2)

Publications

No (2)

Tag

GST (1)

His-T7 (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human ANK1 / Ankyrin Protein (Recombinant His-T7) (aa32-369) - LS-G24400

Source:

E. coli

Tag:

His-T7

Molecular Weight:

40.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human ANK1 / Ankyrin Protein (Recombinant GST) (Full Length) - LS-G27450

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.79 kDa

Price:

10 µg/$479; 25 µg/$670

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