ANGPT1 / Angiopoietin-1

angiopoietin 1

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

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Products

Proteins (19)

Type

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (2)

Recombinant (16)

Target

ANGPT1 / Angiopoietin-1 (19)

Publications

No (19)

Tag

DDK (Flag) (1)

Fc, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (7)

His, C-Terminal (1)

His, N-Terminal (3)

His, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Dog (2)

Human (11)

Mouse (3)

Rat (2)

Source

293T Cells (1)

CHO Cells (1)

E. coli (10)

HEK 293 Cells (2)

HeLa Cells (1)

Human (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (4)

Supernatant (1)

Low Endotoxin Level

Low endotoxin level (3)

Biologically Active

Biologically active (1)

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant Fc, N-terminus) - LS-G146488

Source:

Human

Tag:

Fc, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

53.9 kDa

Price:

10 µg/$317; 50 µg/$529

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa16-498) - LS-G21689

Source:

E. coli

Tag:

His

Molecular Weight:

60 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat ANGPT1 / Angiopoietin-1 Protein (Recombinant His, N-Terminal) (Asn304-Ala450) - LS-G11244

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

18.6 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Dog ANGPT1 / Angiopoietin-1 Protein (Recombinant His, N-terminus) (aa266-497) - LS-G11242

Source:

E. coli

Tag:

His, N-terminus

Molecular Weight:

28.1 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse ANGPT1 / Angiopoietin-1 Protein (Recombinant His, N-Terminal) (Ser20-Phe498) - LS-G96943

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

57 kDa

Price:

10 µg/$265; 50 µg/$315

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant His, C-Terminal) - LS-G116

Source:

HeLa Cells

Tag:

His, C-Terminal

Biological Activity:

Biologically active

Endotoxin Level:

Less than 0.1 ng/µg of protein (less than 1EU/µg).

Molecular Weight:

60.0-70.0 kDa

Price:

5 µg/$268; 20 µg/$349

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Dog ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa148-266) - LS-G11240

Source:

E. coli

Tag:

His

Molecular Weight:

15.4 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Mouse ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa35-231) - LS-G11245

Source:

E. coli

Tag:

His

Molecular Weight:

24.2 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa284-452) - LS-G11246

Source:

E. coli

Tag:

His

Molecular Weight:

21.0 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Mouse ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa253-429) - LS-G11247

Source:

E. coli

Tag:

His

Molecular Weight:

22.0 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa21-228) - LS-G11243

Source:

E. coli

Tag:

His

Molecular Weight:

25.6 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G57767

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ANGPT1 / Angiopoietin-1 Protein (Over-Expression Cell Culture Supernatant His, N-Terminal) (His16-Phe498) - LS-G96942

Source:

HEK 293 Cells

Tag:

His, N-Terminal

Molecular Weight:

~58 kDa

Price:

200 µl/$283

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ANGPT1 / Angiopoietin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99341

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.3 kDa

Price:

100 µg/$710

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Human ANGPT1 / Angiopoietin-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80746

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

57.3 kDa

Price:

20 µg/$215

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant DDK (Flag)) (aa284-498) - LS-G3981

Source:

CHO Cells

Tag:

DDK (Flag)

Endotoxin Level:

Less than 0.05 EU/µg protein (determined by LAL method).

Molecular Weight:

35kDa (SDS-PAGE)

Price:

10 µg/$365

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant GST) (Full Length) - LS-G27451

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

83.9 kDa

Price:

2 µg/$439

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Rat ANGPT1 / Angiopoietin-1 Protein (Recombinant His) (aa20-497) - LS-G22794

Source:

Yeast

Tag:

His

Molecular Weight:

57.4 kD

Price:

1 mg/$1,683; 100 µg/$499; 20 µg/$364

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Human ANGPT1 / Angiopoietin-1 Protein (Recombinant) - LS-G1459

Source:

E. coli

Tag:

None

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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