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ANAPC15
anaphase promoting complex subunit 15
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. In the complex, plays a role in the release of the mitotic checkpoint complex (MCC) from the APC/C: not required for APC/C activity itself, but promotes the turnover of CDC20 and MCC on the APC/C, thereby participating in the responsiveness of the spindle assembly checkpoint. Also required for degradation of CDC20.
| Gene Name: | anaphase promoting complex subunit 15 |
| Synonyms: | ANAPC15, APC15, DKFZP564M082, HSPC020, C11orf51 |
| Target Sequences: | NM_014042 NP_054761.1 P60006 |
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