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AMN is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
Gene Name: | amnion associated transmembrane protein |
Synonyms: | AMN, Amnionless, PRO1028, Amnionless homolog (mouse), Protein amnionless |
Target Sequences: | NM_030943 NP_112205.2 Q9BXJ7 |
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