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Vector Laboratories, Inc.
6737 Mowry Ave
Newark, CA 94560
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AMICA / JAML

adhesion molecule, interacts with CXADR antigen 1

Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.

Gene Name: adhesion molecule, interacts with CXADR antigen 1
Synonyms: AMICA1, AMICA, CREA7-1, CREA7-4, Adhesion molecule AMICA, Gm638, Junctional adhesion molecule, JAML
Target Sequences: NP_694938.2 Q86YT9

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ELISA Kits (2)
Custom (1)
Sandwich (1)
AMICA / JAML (2)
Human (2)
96-Well Microplate (1)
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Cell Culture Supernatants (1)
Citrate Plasma (1)
EDTA Plasma (1)
Heparin Plasma (1)
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AMICA / JAML ELISA Kit
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Custom
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
1 Plate/$635
AMICA / JAML ELISA Kit
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Sandwich
Human
62.5 - 4000 pg/ml
Cell Culture Supernatants, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$699
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).