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Homo sapiens S-adenosylmethionine decarboxylase 1 (AMD1)is an important intermediate enzyme in polyamine biosynthesis. The polyamines spermine, spermidine, and putrescine are low-molecular-weight aliphatic amines essential for cellular proliferation and tumor promotion. An AMD pseudogene, AMD2, is found on chromosome X. The AMD1 gene spans 22 kb comprised of 9 exons and 8 introns and encoding two species of mRNA of 2.1 and 3.4-3.6 kb originating from the use of two different polyadenylation signals. The pro-protein is an approximate 38.3 kD which is known to undergo processing at amino acid 68 to yield two fragments of 32- and 6-kD.
Gene Name: | adenosylmethionine decarboxylase 1 |
Synonyms: | AMD1, ADOMETDC, AMD, SAMDC |
Target Sequences: | NM_001634 NP_001625.2 P17707 |
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