ALOXE3

Arachidonate Lipoxygenase 3

Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced dioxygenase activity compared to other lipoxygenases. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols. The dioxygenase activity requires a step of activation of the enzyme by molecular oxygen. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.

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Products

Antibodies (15)

ELISA Kits (4)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (2)

Sandwich (3)

Sandwich CLIA (1)

Target

ALOXE3 (23)

Reactivity

Human (19)

Mouse (9)

Rat (2)

Application

IHC (4)

IHC-P (2)

WB (14)

ELISA (9)

Host

rabbit (14)

mouse (1)

Isotype

IgG (11)

Clonality

polyclonal pc (15)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (2)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (10)

Epitope

aa223-252 (7)

aa334-599 (2)

aa1-280 (1)

aa1-294 (1)

Publications

No (23)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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ALOXE3 Antibody (aa223-252) LS-C156292

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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ALOXE3 Antibody (aa334-599) LS-C179034

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa334-599) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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ALOXE3 Antibody (aa334-599) LS-C178646

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa334-599) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$332

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ALOXE3 Antibody (aa1-280) LS-C379349

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa1-280) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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ALOXE3 Antibody (aa1-294) LS-C185876

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa1-294) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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ALOXE3 Antibody (aa223-252) LS-C319438

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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ALOXE3 Antibody (aa223-252, Biotin) LS-C232561

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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ALOXE3 Antibody (aa223-252, FITC) LS-C232563

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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ALOXE3 Antibody (aa223-252, Azide-free, HRP) LS-C249403

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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ALOXE3 Antibody (aa223-252, APC) LS-C232562

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

ALOXE3 Antibody (aa223-252, PE) LS-C232564

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal (aa223-252) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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ALOXE3 Antibody LS-C764005

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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ALOXE3 Antibody LS-C409781

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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ALOXE3 Antibody LS-C482986

Antibody:

ALOXE3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

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ALOXE3 Antibody LS-C306213

Antibody:

ALOXE3 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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Human ALOXE3 (Sandwich ELISA) ELISA Kit - LS-F7304

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$730

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Human ALOXE3 (Sandwich ELISA) ELISA Kit - LS-F35315

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Human ALOXE3 Protein (Recombinant GST) (Full Length) - LS-G34857

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

106.9 kDa

Price:

2 µg/$439

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Human ALOXE3 (CLIA) ELISA Kit - LS-F29371

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

62.5 - 4000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$656

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Human ALOXE3 Protein (Recombinant GST, N-terminus) (aa1-97) - LS-G63031

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ALOXE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91532

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.4 kDa

Price:

20 µg/$215

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ALOXE3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110643

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

80.4 kDa

Price:

100 µg/$710

Select

Human ALOXE3 (Sandwich ELISA) ELISA Kit - LS-F21934

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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